What is the Z-PHE-ONP?

Z-PHE-ONP is , while it's Molecular Formula is C23H20 N2 O6. Used in Scientific Research: Z-Phe-ONP is used as a synthetic substrate for measuring the activity of proteolytic enzymes, particularly chymotrypsin, which is responsible for protein breakdown. Its application in this field is crucial for understanding enzyme function and behavior. Used in Enzyme Specificity Studies: Z-Phe-ONP is used as a tool in enzyme specificity studies, where its color change upon interaction with the targeted enzymes allows for accurate quantification. This property makes it a valuable resource for researchers studying enzyme interactions and specificity. Used in Medical Research: Although not explicitly mentioned in the provided materials, Z-Phe-ONP's role in measuring enzyme activity and specificity could potentially be applied in medical research to develop targeted therapies or diagnostic tools for various diseases and conditions. Further studies would be required to explore these possibilities.

What is the CAS number for Z-PHE-ONP?

The CAS number of Z-PHE-ONP is 2578-84-9.

What is Z-PHE-ONP (2578-84-9) used for?

Z-Phe-ONP, also known as N-(3-(2-Furyl)acryloyl)-Phe-ONp, is a chemical compound that serves as a synthetic substrate in scientific and medical research. It is specifically designed to measure the activity of proteolytic enzymes, such as chymotrypsin, which is involved in protein breakdown. Z-Phe-ONP is also utilized in enzyme specificity studies due to its color change, providing accurate quantification. Z-PHE-ONP is recognized for its sensitivity and specificity to the targeted enzymes. However, there is limited information on its toxicity or potential hazards, suggesting that further research on its uptake and biodegradability may be necessary.InChI:InChI=1/C23H20N2O6/c26-22(31-20-13-11-19(12-14-20)25(28)29)21(15-17-7-3-1-4-8-17)24-23(27)30-16-18-9-5-2-6-10-18/h1-14,21H,15-16H2,(H,24,27)/t21-/m0/s1

What is the Z-PHE-ONP?

Z-PHE-ONP is , while it's Molecular Formula is C23H20 N2 O6. Used in Scientific Research: Z-Phe-ONP is used as a synthetic substrate for measuring the activity of proteolytic enzymes, particularly chymotrypsin, which is responsible for protein breakdown. Its application in this field is crucial for understanding enzyme function and behavior. Used in Enzyme Specificity Studies: Z-Phe-ONP is used as a tool in enzyme specificity studies, where its color change upon interaction with the targeted enzymes allows for accurate quantification. This property makes it a valuable resource for researchers studying enzyme interactions and specificity. Used in Medical Research: Although not explicitly mentioned in the provided materials, Z-Phe-ONP's role in measuring enzyme activity and specificity could potentially be applied in medical research to develop targeted therapies or diagnostic tools for various diseases and conditions. Further studies would be required to explore these possibilities.

What is the CAS number for Z-PHE-ONP?

The CAS number of Z-PHE-ONP is 2578-84-9.

What is Z-PHE-ONP (2578-84-9) used for?

Z-Phe-ONP, also known as N-(3-(2-Furyl)acryloyl)-Phe-ONp, is a chemical compound that serves as a synthetic substrate in scientific and medical research. It is specifically designed to measure the activity of proteolytic enzymes, such as chymotrypsin, which is involved in protein breakdown. Z-Phe-ONP is also utilized in enzyme specificity studies due to its color change, providing accurate quantification. Z-PHE-ONP is recognized for its sensitivity and specificity to the targeted enzymes. However, there is limited information on its toxicity or potential hazards, suggesting that further research on its uptake and biodegradability may be necessary.InChI:InChI=1/C23H20N2O6/c26-22(31-20-13-11-19(12-14-20)25(28)29)21(15-17-7-3-1-4-8-17)24-23(27)30-16-18-9-5-2-6-10-18/h1-14,21H,15-16H2,(H,24,27)/t21-/m0/s1

Z-PHE-ONP

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Z-PHE-ONP

Name Z-PHE-ONP
CAS 2578-84-9
Purity 99%

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Product Details

Bulk supply high purity Z-PHE-ONP 2578-84-9, Paid sample available

Molecular Formula: C23H20 N2 O6
Molecular Weight: 420.422
Vapor Pressure: 1.35E-15mmHg at 25°C
Melting Point: 126-127oC
Boiling Point: 626.2°Cat760mmHg
PKA: 10.62±0.46(Predicted)
Flash Point: 332.5°C
PSA： 110.45000
Density: 1.303g/cm³
LogP: 4.95200

Z-PHE-ONP(Cas 2578-84-9) Usage

General Description

Z-Phe-ONP, also known as N-(3-(2-Furyl)acryloyl)-Phe-ONp, is a chemical compound often used in scientific and medical research. It is a type of synthetic substrate used to measure the activity of proteolytic enzymes, specifically chymotrypsin, an enzyme responsible for protein breakdown. Z-Phe-ONP is also used in enzyme specificity studies due to its change in color, which allows for accurate quantification. It is known for its sensitivity and specificity to the targeted enzymes. However, information on its toxicity or potential hazards is not widely available, indicating that uptake and biodegradability studies may still be needed.

InChI:InChI=1/C23H20N2O6/c26-22(31-20-13-11-19(12-14-20)25(28)29)21(15-17-7-3-1-4-8-17)24-23(27)30-16-18-9-5-2-6-10-18/h1-14,21H,15-16H2,(H,24,27)/t21-/m0/s1

2578-84-9 Relevant articles

Catalysis in peptide synthesis with active esters. I. Bifunctional catalysis in the aminolysis of benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester in dioxane.

Nakamizo

, p. 1071 - 1077 (1969)

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides

Kokkala, Paraskevi,Mpakali, Anastasia,Mauvais, Francois-Xavier,Papakyriakou, Athanasios,Daskalaki, Ira,Petropoulou, Ioanna,Kavvalou, Sofia,Papathanasopoulou, Mirto,Agrotis, Stefanos,Fonsou, Theodora-Markisia,Van Endert, Peter,Stratikos, Efstratios,Georgiadis, Dimitris

supporting information, p. 9107 - 9123 (2016/10/22)

The oxytocinase subfamily of M1 aminopep...

Synthesis and evaluation of peptidic irreversible inhibitors of tissue transglutaminase

Pardin, Christophe,Gillet, Steve M.F.G.,Keillor, Jeffrey W.

, p. 8379 - 8385 (2008/02/05)

Herein we report the synthesis and the e...

NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF

-

Page 116-117, (2010/02/09)

An arylamidine derivative represented by...

Fairly marked enantioselectivity for the hydrolysis of amino acid esters by chemically modified enzymes

Yano, Yoshihiro,Shimada, Kenji,Okai, Jiro,Goto, Koichi,Matsumoto, Yoko,Ueoka, Ryuichi

, p. 1314 - 1318 (2007/10/03)

The hydrolysis (deacylation) of enantiom...

2578-84-9 Process route

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1161-13-3
N-Cbz-L-Phe

: 2578-84-9
N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester

Conditions

Conditions	Yield
With N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic azide; triethylamine; In dichloromethane;	100%
With pyridine; 2,6-di-tert-butyl-4-methyl-phenol; In benzene; for 12h;	81%
With pyridine; diphenyl hydrogen phosphite; mercury dichloride;
With N-trifluoroacetylimidazole;
With dicyclohexyl-carbodiimide;

With dicyclohexyl-carbodiimide;
With dicyclohexyl-carbodiimide; In chloroform; at 25 ℃; for 4h;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 20 ℃; for 4h;

: 1161-13-3
N-Cbz-L-Phe

: 7693-46-1
4-Nitrophenyl chloroformate

: 2578-84-9
N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester

Conditions

Conditions	Yield
With dmap; triethylamine; In acetonitrile; at 4 ℃; for 0.833333h;	68%
With dmap; triethylamine; In acetonitrile; at 20 ℃; for 0.75h;

2578-84-9 Upstream products

23485-35-0
tris(p-nitrophenyl)-phosphite
1161-13-3
N-Cbz-L-Phe
100-02-7
4-nitro-phenol
538-75-0
dicyclohexyl-carbodiimide

2578-84-9 Downstream products

209954-25-6
phenylalanine-(4-nitro-phenyl ester); hydrobromide
14470-31-6
(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-3-methylbutanoate
860-55-9
(2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoyl)amino]-3-hydroxypropanoic acid
31025-16-8
Z-Phe-Glu(OCMe₃)-OCH₃

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Z-PHE-ONP

Z-PHE-ONP

Bulk supply high purity Z-PHE-ONP 2578-84-9, Paid sample available

Z-PHE-ONP(Cas 2578-84-9) Usage

2578-84-9 Relevant articles

Catalysis in peptide synthesis with active esters. I. Bifunctional catalysis in the aminolysis of benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester in dioxane.

Nakamizo

, p. 1071 - 1077 (1969)

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides

Kokkala, Paraskevi,Mpakali, Anastasia,Mauvais, Francois-Xavier,Papakyriakou, Athanasios,Daskalaki, Ira,Petropoulou, Ioanna,Kavvalou, Sofia,Papathanasopoulou, Mirto,Agrotis, Stefanos,Fonsou, Theodora-Markisia,Van Endert, Peter,Stratikos, Efstratios,Georgiadis, Dimitris

supporting information, p. 9107 - 9123 (2016/10/22)

Synthesis and evaluation of peptidic irreversible inhibitors of tissue transglutaminase

Pardin, Christophe,Gillet, Steve M.F.G.,Keillor, Jeffrey W.

, p. 8379 - 8385 (2008/02/05)

NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF

-

Page 116-117, (2010/02/09)

Fairly marked enantioselectivity for the hydrolysis of amino acid esters by chemically modified enzymes

Yano, Yoshihiro,Shimada, Kenji,Okai, Jiro,Goto, Koichi,Matsumoto, Yoko,Ueoka, Ryuichi

, p. 1314 - 1318 (2007/10/03)

2578-84-9 Process route

2578-84-9 Upstream products

2578-84-9 Downstream products

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